Fluorescent probe for the identification of potent inhibitors of the macrophage infectivity potentiator (Mip) protein of Burkholderia pseudomallei

• Nicolas Julian Scheuplein,
• Theresa Lohr,
• Mirella Vivoli Vega,
• ...
• Lukas Kirchner,
• Nicholas J. Harmer,
• Ulrike Holzgrabe

In Vitro Three-dimensional (3D) Cell Culture Tools for Spheroid and Organoid Models

• Sang-Yun Lee,
• In-Seong Koo,
• Hyun Ju Hwang,
• Dong Woo Lee

Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance

• Henry Kim,
• Nathalie Weidner,
• Céline Ronin,
• ...
• Anders Pedersen,
• Fredrik R. Zetterberg,
• Robert J. Slack

Comparison of two supporting matrices for patient-derived cancer cells in 3D drug sensitivity and resistance testing assay (3D-DSRT)

• Michaela Feodoroff,
• Piia Mikkonen,
• Laura Turunen,
• ...
• Astrid Murumägi,
• Olli Kallioniemi,
• Vilja Pietiäinen

A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer's disease

• Ramya Visvanathan,
• Tadanobu Utsuki,
• Daniel E. Beck,
• ...
• Andrew Mesecar,
• Zhong-Yin Zhang,
• Karson S. Putt

Merging cultures and disciplines to create a drug discovery ecosystem at Virginia commonwealth university: Medicinal chemistry, structural biology, molecular and behavioral pharmacology and computational chemistry

• Glen E. Kellogg,
• Yana Cen,
• Malgorzata Dukat,
• ...
• Shijun Zhang,
• Yan Zhang,
• Umesh R. Desai

High throughput assay for compounds that boost BDNF expression in neurons

• Guey-Ying Liao,
• Haifei Xu,
• Justin Shumate,
• Louis Scampavia,
• Timothy Spicer,
• Baoji Xu

Mathematical relationships between control group variability and assay quality metrics

• Andrew Lim

Fragment-based drug discovery of small molecule ligands for the human chemokine CCL28

• Angela L. Zhou,
• Davin R. Jensen,
• Francis C. Peterson,
• ...
• Michael B. Dwinell,
• Brian C. Smith,
• Brian F. Volkman

An acute respiratory distress syndrome drug development collaboration stimulated by the Virginia Drug Discovery Consortium

• John S. Lazo,
• Ruben M.L. Colunga-Biancatelli,
• Pavel. A. Solopov,
• John D. Catravas

High-throughput method to analyze the cytotoxicity of CAR-T Cells in a 3D tumor spheroid model using image cytometry

• David Zurowski,
• Samir Patel,
• Daniel Hui,
• ...
• Bo Lin,
• Andrea Moore,
• Leo Li-Ying Chan

Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures

• Alemu Takele Assefa,
• Bie Verbist,
• Emmanuel Gustin,
• Danielle Peeters

High throughput screening of 0.5 million compounds against CRAF using Alpha CETSA^Ⓡ

• Hannah Rowlands,
• Kirsten Tschapalda,
• Carolyn Blackett,
• ...
• Martin Packer,
• Laurence Arnold,
• Geoffrey A. Holdgate

High throughput screening for drugs that inhibit 3C-like protease in SARS-CoV-2

• Emery Smith,
• Meredith E. Davis-Gardner,
• Ruben D. Garcia-Ordonez,
• ...
• Patrick Griffin,
• Michael Farzan,
• Timothy P. Spicer

Using chemical and biological data to predict drug toxicity

• Anika Liu,
• Srijit Seal,
• Hongbin Yang,
• Andreas Bender

High-content phenotypic screen to identify small molecule enhancers of Parkin-dependent ubiquitination and mitophagy

• Roberta Tufi,
• Emily H. Clark,
• Tamaki Hoshikawa,
• ...
• Kunitoshi Takeda,
• James M. Staddon,
• Thomas Briston

High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons

• Elizabeth R. Sharlow,
• Danielle C. Llaneza,
• William E. Grever,
• ...
• Anna J. Mendelson,
• George S. Bloom,
• John S. Lazo

High-throughput screening for identifying acetylcholinesterase inhibitors: Insights on novel inhibitors and the use of liver microsomes

• Michael F. Santillo,
• Menghang Xia

High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes

HTS assays for multiple human nAChR subtypes

• Michelle Kassner,
• J. Brek Eaton,
• Nanyun Tang,
• ...
• Nathalie Meurice,
• Hongwei Holly Yin,
• Paul Whiteaker

Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells

• Johannes H. Wilbertz,
• Julia Frappier,
• Sandra Muller,
• ...
• Walter Englaro,
• Lisa M. Stanek,
• Barbara Calamini

Identification of positive modulators of TRPM5 channel from a high-throughput screen using a fluorescent membrane potential assay

• Caterina Virginio,
• Laura Aldegheri,
• Selena Nola,
• ...
• Alessio Barilli,
• Mark Sabat,
• Richard Myers

Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines

• David A. Close,
• Paul A. Johnston